|
|
S-adenosyl-L-methionine + (S)-Coclaurine <=> H+ + (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine
|
2.1.1.115
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
2.1.1.140
(S)-coclaurine-N-methyltransferase
|
–
–
|
MK
|
| |
BRENDA:
BR29467
KEGG:
R04692
MetaCyc:
2.1.1.140-RXN
|
|
|
|
(S)-N-methylcoclaurine + reduced_flavodoxin + O2 <=> (S)-3''-hydroxy-N-methylcoclaurine + flavin + H2O
|
1.14.14.102
N-methylcoclaurine 3'-monooxygenase
|
–
|
K
|
| |
BRENDA:
BR29147
KEGG:
R05732
|
|
|
|
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + reduced_flavodoxin + O2 <=> Berbamunine + flavin + 2 H2O
|
1.14.19.66
berbamunine synthase
|
–
|
K
|
| |
BRENDA:
BR36941
KEGG:
R04694
|
|
|
|
(S)-N-methylcoclaurine + NADPH + H+ + O2 <=> (S)-3''-hydroxy-N-methylcoclaurine + NADP+ + H2O
|
1.14.13.71
N-methylcoclaurine 3'-monooxygenase
1.14.14.102
N-methylcoclaurine 3'-monooxygenase
|
–
–
|
|
| |
BRENDA:
BS442121
SABIO-RK:
5325
|
|
|
|
(S)-N-methylcoclaurine + O2 + reduced_acceptor <=> 3''-Hydroxy-N-methyl-(S)-coclaurine + H2O + acceptor
|
1.14.18.1
tyrosinase
|
–
|
|
| |
KEGG:
R04693
|
|
|
|
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine <=> tubocurarine
|
not assigned
|
–
|
|
| |
KEGG:
R08458
|
|
|
|
2 (S)-N-methylcoclaurine <=> tetrandrine
|
not assigned
|
–
|
|
| |
KEGG:
R08459
|
|
|
|
(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced_[NADPH-hemoprotein_reductase] <=> Berbamunine + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.19.66
berbamunine synthase
|
–
|
M
|
| |
MetaCyc:
1.1.3.34-RXN
|
|
|
|
(S)-N-methylcoclaurine + O2 + reduced_[NADPH-hemoprotein_reductase] <=> (S)-3''-hydroxy-N-methylcoclaurine + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.102
N-methylcoclaurine 3'-monooxygenase
|
–
|
M
|
| |
MetaCyc:
1.14.13.71-RXN
|
|
|
|
(S)-N-methylcoclaurine + reduced_flavodoxin + O2 <=> 2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + flavin + 2 H2O
|
1.14.19.51
(S)-corytuberine synthase
|
–
|
|
| |
BRENDA:
BS438599
|
|
|
|
(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + (S)-Coclaurine + reduced_flavodoxin + O2 <=> Berbamunine + (R,R)-guattegaumerine + (R,S)-2''-norberbamunine + flavin + H2O
|
1.14.19.66
berbamunine synthase
|
–
|
|
| |
BRENDA:
BS259655
|
|
|
|
2 (S)-N-methylcoclaurine + 2 (R)-N-methylcoclaurine + reduced_flavodoxin + O2 <=> Berbamunine + (R,R)-guattegaumerine + flavin + H2O
|
1.14.19.66
berbamunine synthase
|
–
|
|
| |
BRENDA:
BS259654
|
|
|
|
(S)-N-methylcoclaurine + O2 <=> (S)-Coclaurine + H2O2
|
1.21.3.3
reticuline oxidase
|
–
|
|
| |
BRENDA:
BS260025
|
|
|
|
S-adenosyl-L-methionine + (R)-coclaurine <=> S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
|
2.1.1.140
(S)-coclaurine-N-methyltransferase
|
–
|
|
| |
BRENDA:
BS377619
|
|
|
|
S-adenosyl-L-methionine + (S)-N-methylcoclaurine <=> S-adenosyl-L-homocysteine + (S)-N,N-dimethylcoclaurine
|
2.1.1.337
reticuline N-methyltransferase
|
–
|
|
| |
BRENDA:
BS456362
|
|
|
|
(S)-N-methylcoclaurine + ascorbate + O2 <=> (S)-3''-hydroxy-N-methylcoclaurine + dehydroascorbate + H2O
|
1.14.17.B1
|
–
|
|
| |
BRENDA:
BR49859
|
|
